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Medical Devices · ISO 13485 / 21 CFR Part 11

Medical devices is one of manufacturing's most heavily regulated fields: the ISO 13485 system, FDA 21 CFR Part 11 electronic signatures / audit trail, UDI unique identification, the CAPA workflow, and sterilization validation. SBK MES turns these compliance requirements into out-of-the-box capabilities.

ISO
13485 Compliance
21 CFR
Part 11 Met
UDI
Unique Identification
Industry Pain Points vs. MES Solutions

6 Typical Challenges of Medical-Device Factories

High compliance demands and high cost of failure require every step to be traceable and provable

📝 Pain Point 1: Electronic Signatures

21 CFR Part 11 requires electronic signatures on all key operations → electronic signatures across all modules + two-factor authentication

📜 Pain Point 2: Audit Trail

Every data change must trace the who / when / why → full-field audit logs, never deleted

📱 Pain Point 3: UDI Identification

FDA requires UDI unique identification for devices → DI + PI dual-segment coding + auto-marking and GUDID upload

🔁 Pain Point 4: CAPA Workflow

Deviations / complaints / recalls must go through CAPA → templated CAPA workflow + tracking + effectiveness verification

Pain Point 5: Sterilization Validation

Each sterilization batch needs parameters + chemical indicator + biological indicator → sterilization parameters auto-recorded + three-way validation

📚 Pain Point 6: DHR Batch Records

Each batch must have complete DHR documentation → MES auto-generates the DHR, including full-operation parameters / inspection / signatures

mes.shangbangke.com/medical/audit21 CFR Part 11
ES
E-Sign Audit Trail — Batch BR-0512
CSVE-sign
TimeAction / valuesBySign
14:02Dosing verify 200kgLiSigned
14:18Temp 119→121℃WangSigned
15:05QA release reviewZhangPending
ALCOA+ integrity checkSystemPass

21 CFR Part 11 Electronic Signatures + Audit Trail

FDA 21 CFR Part 11 is the compliance ceiling of the medical / pharma industry: electronic records and signatures must carry the same legal force as paper signatures, and all changes must be traceable. SBK MES makes this compliance a built-in capability, with no extra integration needed.

  • Electronic signatures: username + password + action binding, non-repudiable
  • Audit trail: each change records who / when / before & after values / reason
  • System validation (CSV): IQ / OQ / PQ documentation included
  • Data integrity ALCOA+: original / traceable / contemporaneous
mes.shangbangke.com/medical/udiUDI submit
UD
UDI Identifier — Single-Use Catheter
MarkSubmit GUDID
(01)06901234567890
LOT-2605-08
SN-000128
(11)260512
(17)280511
GUDID submitted

UDI Unique Identification: From Marking to GUDID Submission

FDA requires devices to carry a UDI unique identifier, comprising the DI (device identifier) + PI (production identifier). SBK MES closes the full UDI loop — generation / marking / database submission — including integration with the GUDID / EU EUDAMED databases.

  • DI portion: auto-pulled from the device-model dictionary
  • PI portion: lot number + serial number + production date + expiry
  • UDI codes auto-printed onto packaging and the device itself
  • UDI data auto-submitted to GUDID / EUDAMED
mes.shangbangke.com/medical/capaISO 13485
CA
CAPA Workflow — CAPA-0231
RCASubmit
Deviation
Logged + disposition
Root cause
5 Why confirmed
CAPA action
Implement 66%
Verify
3 batches tracked

Each step signed · retrievable for audit

CAPA Workflow: From Deviation to Effectiveness Verification

ISO 13485 requires all deviations / complaints / nonconformities to go through CAPA: corrective actions + preventive actions + effectiveness verification. SBK MES templates the CAPA workflow, with every step traceable and signed, to the auditor's satisfaction.

  • Deviation logging: symptom / time / impact scope / urgent disposition
  • Root-cause analysis (RCA): fishbone / 5 Why / 8D tools
  • Corrective & preventive actions: feasibility assessment + implementation plan
  • Effectiveness verification: tracked and verified over N batches
Use Cases

In Action Across Medical-Device Sub-Sectors

Sterile Consumables

Syringes / catheters / surgical kits, with strong traceability + sterilization validation + UDI

Implantable Devices

Bone screws / cardiac stents — Class III devices with the strictest traceability down to each SN

IVD In-Vitro Diagnostic Reagents

Reagent kit batches bound to standard curves, with expiry + storage/transport temperature traced throughout

Medical Equipment Assembly

Large medical equipment in ETO mode, with installation & commissioning reports + integrated after-sales repair

Related Features

Core Modules Behind the Medical Solution

These MES modules together form the medical-device solution

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